Testosterone Perturbs Epidermal Permeability Barrier Homeostasis
نویسندگان
چکیده
منابع مشابه
Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders.
BACKGROUND A large number of skin diseases, including atopic dermatitis and psoriasis, appear to be precipitated or exacerbated by psychological stress. Nevertheless, the specific pathogenic role of psychological stress remains unknown. In 3 different murine models of psychological stress, it was recently shown that psychological stress negatively impacts cutaneous permeability barrier function...
متن کاملPhysical and Chemical Factors that Improve Epidermal Permeability Barrier Homeostasis
For terrestrial creatures, the water-impermeable barrier function of the skin is essential to maintain life in the face of environmental dryness. Stratum corneum, which plays a crucial role in the barrier function, is composed of two components, i.e., protein-rich nonviable cells and intercellular lipid domains. When the barrier function is damaged by a surfactant, organic solvent or tape strip...
متن کاملThe Role of Epidermal Lipids in Cutaneous Permeability Barrier Homeostasis
The permeability barrier is required for terrestrial life and is localized to the stratum corneum, where extracellular lipid membranes inhibit water movement. The lipids that constitute the extracellular matrix have a unique composition and are 50% ceramides, 25% cholesterol, and 15% free fatty acids. Essential fatty acid deficiency results in abnormalities in stratum corneum structure function...
متن کاملStress alters cutaneous permeability barrier homeostasis.
Recent studies have shown that psychological stress can influence cutaneous barrier function, suggesting that this form of stress could trigger or aggravate skin disease. In the present study, we demonstrate that transfer of hairless mice to a different cage delays barrier recovery rates. Pretreatment with a phenothiazine sedative, chlorpromazine, before transfer of animals restored the kinetic...
متن کاملThematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis.
The permeability barrier is required for terrestrial life and is localized to the stratum corneum, where extracellular lipid membranes inhibit water movement. The lipids that constitute the extracellular matrix have a unique composition and are 50% ceramides, 25% cholesterol, and 15% free fatty acids. Essential fatty acid deficiency results in abnormalities in stratum corneum structure function...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2001
ISSN: 0022-202X
DOI: 10.1046/j.1523-1747.2001.01281.x